Oct. 21, 2009 -- Junk food elicits addictive behavior in rats similar to the behaviors of rats addicted to heroin, a new study finds. Pleasure centers in the brains of rats addicted to high-fat, high-calorie diets became less responsive as the binging wore on, making the rats consume more and more food. The results, presented October 20 at the Society for Neuroscience's annual meeting, may help explain the changes in the brain that lead people to overeat.

"This is the most complete evidence to date that suggests obesity and drug addiction have common neurobiological underpinnings," says study coauthor Paul Johnson of the Scripps Research Institute in Jupiter, Fla.

To see how junk food affects the brain's natural reward system -- the network of nerve cells that release feel-good chemicals -- Johnson started at the grocery store. He loaded up on typical Western fare, including Ho Hos, sausage, pound cake, bacon and cheesecake. Johnson fed rats either a standard diet of high-nutrient, low-calorie chow, or unlimited amounts of the palatable junk food. Rats that ate the junk food soon developed compulsive eating habits and became obese. "They're taking in twice the amount of calories as the control rats," says Johnson's coauthor Paul Kenny, also of Scripps.

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